An anonymous reader shared this report from the Guardian: The number of deaths linked to superbugs that do not respond to frontline antibiotics increased by 17% in England last year, according to official figures that raise concerns about the ongoing increase in antimicrobial resistance.

The figures, released by the UK Health Security Agency, also revealed a large rise in private prescriptions for antibiotics, with 22% dispensed through the private sector in 2024. The increase in private prescribing is partly explained by the Pharmacy First scheme, a flagship policy of Rishi Sunak's government that allows patients to be prescribed antibiotics for common illnesses without seeing a GP, raising questions about whether the shift in prescribing patterns risks contributing to the rise in resistance.

"Antibiotic resistance is one of the greatest health threats we face," said the UKHSA's chief executive, Prof Susan Hopkins. "More people than ever are acquiring infections that cannot be effectively treated by antibiotics. This puts them at greater risk of serious illness and even death, with our poorest communities hit the hardest... It's positive that we've seen antibiotic use fall in England within the NHS but we need to go further, faster," said Hopkins.

"Please remember to only take antibiotics if you have been told to do so by a healthcare professional. Do not save some for later or share them with friends and family. If you have leftover antibiotics, please bring them to a pharmacy for appropriate disposal."

One of the most common viruses in the world could be the cause of lupus, an autoimmune disease with wide-ranging symptoms, according to a new study. From a report: Until now, lupus was somewhat mysterious: No single root cause of the disease had been found, and while there is no cure, there are medications that can treat it.

The research, published in the journal Science Translational Medicine, suggests that Epstein-Barr virus -- which 95% of people acquire at some point in life -- could cause lupus by driving the body to attack its own healthy cells.

It adds to mounting evidence that Epstein-Barr is associated with multiple long-term health issues, including other autoimmune conditions. As this evidence stacks up, scientists have accelerated calls for a vaccine that targets the virus.

"If we now better understand how this fastidious virus is responsible for autoimmune diseases, I think it's time to figure out how to prevent it," said Dr. Anca Askanase, clinical director of the Lupus Center at Columbia University, who wasn't involved in the new research.

Animal testing in science would be phased out faster under a new plan to increase the use of artificial intelligence and 3D bioprinted human tissues, a UK minister has said. The Guardian: The roadmap unveiled by the science minister, Patrick Vallance, backs replacing certain animal tests that are still used where necessary to determine the safety of products such as life-saving vaccines and the impact pesticides have on living beings and the environment. The strategy says phasing out the use of animals in science can only happen when reliable and effective alternative methods with the same level of safety for human exposure can replace them.

The government said new funding for researchers and streamlined regulation would help develop methods such as organ-on-a-chip systems -- tiny devices that mimic how human organs work using real human cells. Greater use of AI to analyse vast amounts of data about molecules and predict whether new medicines will be safe and work well on humans would be deployed, while 3D bioprinted tissues could create realistic human tissue samples, from skin to liver, for testing.

Other plans under the strategy include an end to regulatory testing on animals to assess the potential for skin and eye irritation and skin sensitisation by the end of 2026. By 2027, researchers are expected under the strategy to end tests of the strength of botox on mice, while by 2030 pharmacokinetic studies -- which track how a drug moves through the body over time -- on dogs and non-human primates will be reduced.

After more than a decade of planning, the launch of the African Medicines Agency (AMA) is being celebrated in Mombasa, Kenya, this week at the Seventh Biennial Scientific Conference on Medical Products Regulation in Africa. From a report: The agency's establishment marks a pivotal moment in Africa's public health, at a time when the need for biomedical research conducted in Africa, focused on African health problems, has never been greater. Africa holds higher levels of human genetic diversity than anywhere else on Earth, but this diversity has not been adequately studied. And many globally approved treatments and vaccines for diseases such as HIV/AIDS, malaria and tuberculosis are less effective, and can even be harmful in some people of African ancestry.

This year, cuts of billions of US dollars in international funding for biomedical research and health services in Africa have left millions of people without access to life-saving treatments or, in the case of researchers and health-care workers, unemployed. This demonstrates the immense vulnerability that comes with relying on funding from external donors.

What's more, Africa's phenomenal population growth and pace of urbanization is bringing fresh challenges -- as well as opportunities -- around health and disease. In Africa's cities today, the inhabitants of increasingly affluent neighbourhoods are demanding high-quality medicines and health care. But in low-income areas, high population density, inadequate housing and poor sanitation are facilitating the spread of respiratory and diarrhoeal infections. And everywhere, inadequate diets, air pollution, smoking and physical inactivity are driving increased rates of cardiovascular disease, diabetes and cancer. By 2100, Africa is expected to host 13 of the world's 20 largest cities, and such inequalities are likely to worsen.

"For months, a small company in San Francisco has been pursuing a secretive project: the birth of a genetically engineered baby," reports the Wall Street Journal: Backed by OpenAI chief executive Sam Altman and his husband, along with Coinbase co-founder and CEO Brian Armstrong, the startup — called Preventive — has been quietly preparing what would amount to a biological first. They are working toward creating a child born from an embryo edited to prevent a hereditary disease.... Editing genes in embryos with the intention of creating babies from them is banned in the U.S. and many countries. Preventive has been searching for places to experiment where embryo editing is allowed, including the United Arab Emirates, according to correspondence reviewed by The Wall Street Journal...

Preventive is in the vanguard of a growing number of startups, funded by some of the most powerful people in Silicon Valley, that are pushing the boundaries of fertility and working to commercialize reproductive genetic technologies. Some are working on embryo editing, while others are already selling genetic screening tools that seek to account for the influence of dozens or hundreds of genes on a trait. They say their ultimate goal is to produce babies who are free of genetic disease and resilient against illnesses. Some say they can also give parents the ability to choose embryos that will have higher IQs and preferred traits such as height and eye color. Armstrong, the cryptocurrency billionaire, is leading the charge to make embryo editing a reality. He has told people that gene-editing technology could produce children who are less prone to heart disease, with lower cholesterol and stronger bones to prevent osteoporosis. According to documents and people briefed on his plans, he is already an investor or in talks with embryo editing ventures...

After the Journal approached people close to the company last month to ask about its work, Preventive announced on its website that it had raised $30 million in investment to explore embryo editing. The statement pledged not to advance to human trials "if safety cannot be established through extensive research..." Other embryo editing startups are Manhattan Genomics, co-founded by Thiel Fellow Cathy Tie, and Bootstrap Bio, which plans to conduct tests in Honduras. Both companies are in early stages.
The article notes the only known instance of children born from edited embryos was in 2018, when Chinese scientist He Jiankui "shocked the world with news that he had produced three children genetically altered as embryos to be immune to HIV. He was sentenced to prison in China for three years for the illegal practice of medicine.

"He hasn't publicly shared the children's identities but says they are healthy.

A CRISPR-based drug given to study participants by infusion is raising hopes for a much easier way to lower cholesterol, reports CNN: With a snip of a gene, doctors may one day permanently lower dangerously high cholesterol, possibly removing the need for medication, according to a new pilot study published Saturday in the New England Journal of Medicine.

The study was extremely small — only 15 patients with severe disease — and was meant to test the safety of a new medication delivered by CRISPR-Cas9, a biological sort of scissor which cuts a targeted gene to modify or turn it on or off. Preliminary results, however, showed nearly a 50% reduction in low-density lipoprotein, or LDL, the "bad" cholesterol which plays a major role in heart disease — the No.1 killer of adults in the United States and worldwide. The study, which will be presented Saturday at the American Heart Association Scientific Sessions in New Orleans, also found an average 55% reduction in triglycerides, a different type of fat in the blood that is also linked to an increased risk of cardiovascular disease.

"We hope this is a permanent solution, where younger people with severe disease can undergo a 'one and done' gene therapy and have reduced LDL and triglycerides for the rest of their lives," said senior study author Dr. Steven Nissen, chief academic officer of the Sydell and Arnold Miller Family Heart, Vascular & Thoracic Institute at Cleveland Clinic in Ohio.... Today, cardiologists want people with existing heart disease or those born with a predisposition for hard-to-control cholesterol to lower their LDL well below 100, which is the average in the US, said Dr. Pradeep Natarajan, director of preventive cardiology at Massachusetts General Hospital and associate professor of medicine at Harvard Medical School in Boston...

People with a nonfunctioning ANGPTL3 gene — which Natarajan says applies to about 1 in 250 people in the US — have lifelong levels of low LDL cholesterol and triglycerides without any apparent negative consequences. They also have exceedingly low or no risk for cardiovascular disease. "It's a naturally occurring mutation that's protective against cardiovascular disease," said Nissen, who holds the Lewis and Patricia Dickey Chair in Cardiovascular Medicine at Cleveland Clinic. "And now that CRISPR is here, we have the ability to change other people's genes so they too can have this protection."
"Phase 2 clinical trials will begin soon, quickly followed by Phase 3 trials, which are designed to show the effect of the drug on a larger population, Nissen said."

And CNN quotes Nissen as saying "We hope to do all this by the end of next year. We're moving very fast because this is a huge unmet medical need — millions of people have these disorders and many of them are not on treatment or have stopped treatment for whatever reason."

Microsoft is launching a new MAI Superintelligence Team under Mustafa Suleyman to build practical, controllable AI aimed at digital companions, medical diagnostics, and renewable-energy modeling. "We are doing this to solve real concrete problems and do it in such a way that it remains grounded and controllable," Suleyman wrote. "We are not building an ill-defined and ethereal superintelligence; we are building a practical technology explicitly designed only to serve humanity." CNBC reports: The new Microsoft AI research group will focus on providing useful companions for people that can help in education and other domains, Suleyman wrote in his blog post. It will also pursue narrow areas in medicine and in renewable energy production. "We'll have expert level performance at the full range of diagnostics, alongside highly capable planning and prediction in operational clinical settings," Suleyman wrote.

As investors and analysts are increasingly voicing their concerns about overspending on AI without a clear path to profits, Suleyman said he wants "to make clear that we are not building a superintelligence at any cost, with no limits."

Millions will set their clocks back an hour tonight for Daylight Saving Time — only to set them forward an hour six months later.

But does anyone like doing this, asks Yahoo News: A recent AP-NORC poll found that about half of the American public, 47%, oppose the current daylight saving time system, compared to 40% who neither favor nor oppose the current practice, while 12% favor the current system, which involves most states switching their clocks twice a year.

Of those polled, 56% would prefer to have daylight saving time year-round, meaning less light in the morning for a tradeoff of more light in the evening. While 42% of Americans said they would prefer to have standard time year-round, which means more light in the morning and less light in the evening. And 12% of Americans prefer switching between standard time and daylight saving time.

Sleep doctors would prefer we switch to standard time permanently. "The U.S. should eliminate seasonal time changes in favor of a national, fixed, year-round time," the American Academy of Sleep Medicine said in a statement published in the Journal of Clinical Sleep Medicine last year. "Current evidence best supports the adoption of year-round standard time, which aligns best with human circadian biology and provides distinct benefits for public health and safety."

A top United States regulator plans to unveil a faster approach to approving custom gene-editing treatments, a move designed to unleash a wave of industry investment that will yield cures for patients with rare diseases. From a report: Vinay Prasad, who oversees gene therapies at the Food and Drug Administration, said scientific advances, like Crispr, have forced the agency to relax some of its strict rules. As an example, he cited the case of 10-month-old KJ Muldoon, who this year became the first person in history to have his genes custom edited to cure an inherited disease.

"Regulation has to evolve as fast as science evolves," Prasad said in an interview with Bloomberg News. The agency is "going to be extremely flexible and work very fast with the scientists who want to bring these therapies to kids who need it." Prasad plans to publish a paper in early November outlining the FDA's new approach. He predicted it will spark interest in developing treatments for conditions that may affect only a handful of people.

Gallup: After peaking at a record high of 39.9% in 2022, the U.S. adult obesity rate has gradually declined to 37.0% in 2025. This is a statistically meaningful decrease representing an estimated 7.6 million fewer obese adults compared with three years ago. Meanwhile, diagnoses of diabetes -- a lifetime disease that can be managed but not cured -- have now reached an all-time high of 13.8%. Both metrics are part of the ongoing Gallup National Health and Well-Being Index.

[...] Over the past year, more Americans have turned to Type 2 antidiabetic GLP-1 drugs such as semaglutide (brand names Ozempic and Wegovy) for weight loss purposes. The percentage of adults who report taking this class of medicine specifically for weight loss has increased to 12.4%, compared with 5.8% in February 2024 when Gallup first measured it. Usage among women (15.2%) continues to outpace men (9.7%), but both groups have more than doubled their use in the past year. These results dovetail with increased awareness of the drugs used for weight loss, which has risen from 80% to 89% nationally in the same period.

schwit1 shares a report from IOL: China has enacted a new law regulating social media influencers, requiring them to hold verified professional qualifications before posting content on sensitive topics such as medicine, law, education, and finance, IOL reported. The new law went into effect on Saturday. The regulation was introduced by the Cyberspace Administration of China (CAC) as part of its broader effort to curb misinformation online.

Under the new rules, influencers must prove their expertise through recognized degrees, certifications, or licenses before discussing regulated subjects. Major platforms such as Douyin (China's TikTok), Bilibili, and Weibo are now responsible for verifying influencer credentials and ensuring that content includes clear citations, disclaimers, and transparency about sources. A separate report notes that if influencers are caught talking about the "serious" topics, they will face a fine of up to 100,000 yuan ($14,000).

schwit1 writes: China has enacted a new law regulating social media influencers, requiring them to hold verified professional qualifications before posting content on sensitive topics such as medicine, law, education, and finance, IOL reported. The new law went into effect on Saturday.

The regulation was introduced by the Cyberspace Administration of China (CAC) as part of its broader effort to curb misinformation online. Under the new rules, influencers must prove their expertise through recognized degrees, certifications, or licenses before discussing regulated subjects. Major platforms such as Douyin (China's TikTok), Bilibili, and Weibo are now responsible for verifying influencer credentials and ensuring that content includes clear citations, disclaimers, and transparency about sources.

Audiences expect influencers to be both creative and credible. Yet when they blur the line between opinion and expertise, the impact can be severe. A single misleading financial tip could wipe out someone's savings. A viral health trend could cause real harm. That's why many believe it's time for creators to acknowledge the weight of their influence. However, China's new law raises deeper questions: Who defines "expertise"? What happens to independent creators who challenge official narratives but lack formal credentials? And how far can regulation go before it suppresses free thought?

The proliferation of difficult-to-treat bacterial diseases represents a growing threat, according to the World Health Organization's (WHO) Global Antibiotic Resistance Surveillance Report. Wired: The report reveals that, between 2018 and 2023, antibiotic resistance increased by more than 40 percent in monitored pathogen-drug combinations, with an average annual increase of 5-15 percent. According to data reported by more than 100 countries to WHO's Global Antimicrobial Resistance and Use Surveillance System (GLASS), one in six laboratory-confirmed bacteria in 2023 proved resistant to antibiotic treatment, all related to various common diseases globally.

For the first time, this edition of the report includes prevalence estimates of resistance to 22 antibiotics used to treat urinary tract, gastrointestinal, bloodstream, and gonorrheal conditions. The analysis focused on eight common pathogens: Acinetobacter spp, Escherichia coli, Klebsiella pneumoniae, Neisseria gonorrhoeae, non-typhoidal Salmonella spp, Shigella spp, Staphylococcus aureus, and Streptococcus pneumoniae. The results show that resistant gram-negative bacteria pose the greatest threat. Of particular note are Escherichia coli and Klebsiella pneumoniae, which are associated with bloodstream infections that can lead to sepsis, organ failure, and death. "More than 40 percent of E. coli and more than 55 percent of K. pneumoniae strains worldwide are now resistant to third-generation cephalosporins, the first-choice treatment for these types of infections," the report warns.

An electronic eye implant has restored reading ability to patients blinded by geographic atrophy, a form of dry age-related macular degeneration. Results published Monday in the New England Journal of Medicine showed that 84% of trial participants regained the ability to read letters, numbers, and words after receiving the Prima device.

The microchip measures two millimetres by two millimetres and is implanted beneath the center of the retina. Patients wear augmented reality glasses containing a camera that projects images onto the chip. The device converts light into electrical pulses transmitted to the brain.

Frank Holz, the study's lead author and chair of ophthalmology at the University Hospital of Bonn, called the implant "a paradigm shift in treating late-stage age-related macular degeneration." Mahi Muqit, a consultant at Moorfields Eye Hospital in London, said the trial enabled "meaningful central vision restoration, which has never been done before." The procedure takes less than two hours and requires intensive rehabilitation. Science Corporation, which manufactures the device, has applied for clinical authorization in the United States and Europe.

In Reddit's "Family Medicine" subreddit, a moderator noticed earlier this week that the AI-powered "Reddit Answers" was automatically responding to posters, typically with "something related to what was posted." Unfortunately, that moderator says, Reddit Answers "has been spreading grossly dangerous misinformation."And yet Reddit's moderators "cannot disable this feature."

Elsewhere a healthcare worker described what happened when they tested Reddit Answers: I made a post in r/familymedicine and a link appeared below it with information on treating chronic pain. The first post it cited urged people to stop their prescribed medications and take high-dose kratom which is an illegal (in some states) and unregulated substance. I absolutely do not endorse this...

I also asked about the medical indications for heroin. One answer warned about addiction and linked to crisis and recovery resources. The other connects to a post where someone claims heroin saved their life and controls their chronic pain. The post was encouraging people to stop prescribed medications and use heroin instead. Heroin is a schedule I drug in the US which means there are no acceptable uses. It's incredibly addictive and dangerous. It is responsible for the loss of so many lives...

The AI-generated answers could easily be mistaken as information endorsed by the sub it appears in. r/familymedicine absolutely does not endorse using heroin to treat chronic pain. This feature needs to be disabled in medical and mental health subs, or allow moderators of these subreddits to opt out. Better filters are also needed when users ask Reddit Answers health related questions. If this continues there will be adverse outcomes. People will be harmed. This needs to change.
Two days ago an official Reddit "Admin" posted that "We've made some changes to where Answers appears based on this feedback," adding that beyond that Reddit "will continue to tweak based on what we're seeing and hearing." But the "Family Medicine" subreddit still has a top-of-page announcement warning every user there...

"We do NOT and CANNOT endorse Reddit Answers at this time and urge every user of this sub to disregard anything it says."

Doug Whitney carries a genetic mutation that guaranteed he would develop Alzheimer's disease in his late forties or early fifties. His mother and nine of her thirteen siblings died from the disease. His oldest brother died at 45. The mutation has decimated his family for generations. Whitney is now 76 and remains cognitively healthy. The New York Times has a fascinating long read on Whitney and things happening around him.

Scientists at Washington University School of Medicine in St. Louis have studied Whitney for 14 years. They extract his cerebrospinal fluid and conduct brain scans during his periodic visits from Washington State. His brain contains heavy amyloid deposits but almost no tau tangles in regions associated with dementia. Tau accumulation correlates directly with cognitive decline. Whitney accumulated tau only in his left occipital lobe, an area that does not play a major role in Alzheimer's.

Researchers identified several possibly protective factors in Whitney's biology. His immune system produces a lower inflammatory response than other mutation carriers. He has unusually high levels of heat shock proteins, which prevent proteins from misfolding. Scientists believe his decade working in Navy engine rooms at temperatures reaching 110 degrees may have driven this accumulation. He also carries three gene variants his afflicted relatives lack. His son Brian inherited the mutation and remains asymptomatic at 43. Brian received anti-amyloid drugs in clinical trials. Researchers published their findings on Whitney in Nature Medicine. They described the study as a call for other scientists to help solve the case.

Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi received the Nobel Prize in Physiology or Medicine on Monday for their discoveries about how the immune system regulates itself. The three researchers split 11 million Swedish kroner ($1.17 million). Their work identified regulatory T cells and the FOXP3 gene that controls them. Dr. Sakaguchi spent more than a decade solving a puzzle about the thymus. He discovered that the immune system has a backup mechanism to stop harmful cells from attacking the body's own tissues. Dr. Brunkow and Dr. Ramsdell found the specific gene responsible for this process while studying mice that developed severe autoimmune disease.

More than 200 clinical trials are now underway based on their research. Cancers attract regulatory T cells to block immune attacks. Researchers are developing drugs to turn the immune system against these cancer cells. In autoimmune diseases, regulatory T cells are missing or defective. The FOXP3 gene provides a starting point for drugs that teach the immune system to stop attacking itself.

Currently DNA synthesis companies "deploy biosecurity software designed to guard against nefarious activity," reports the Washington Post, "by flagging proteins of concern — for example, known toxins or components of pathogens." But Microsoft researchers discovered "up to 100 percent" of AI-generated ricin-like proteins evaded detection — and worked with a group of leading industry scientists and biosecurity experts to design a patch. Microsoft's chief science officer called it "a Windows update model for the planet.

"We will continue to stay on it and send out patches as needed, and also define the research processes and best practices moving forward to stay ahead of the curve as best we can."

But is that enough? Outside biosecurity experts applauded the study and the patch, but said that this is not an area where one single approach to biosecurity is sufficient. "What's happening with AI-related science is that the front edge of the technology is accelerating much faster than the back end ... in managing the risks," said David Relman, a microbiologist at Stanford University School of Medicine. "It's not just that we have a gap — we have a rapidly widening gap, as we speak. Every minute we sit here talking about what we need to do about the things that were just released, we're already getting further behind."
The Washington Post notes not every company deploys biosecurity software. But "A different approach, biosecurity experts say, is to ensure AI software itself is imbued with safeguards before digital ideas are at the cusp of being brought into labs for research and experimentation." "The only surefire way to avoid problems is to log all DNA synthesis, so if there is a worrisome new virus or other biological agent, the sequence can be cross-referenced with the logged DNA database to see where it came from," David Baker, who shared the Nobel Prize in chemistry for his work on proteins, said in an email.

Bruce66423 shares a report from The Guardian: Those diagnosed as small children typically have distinct genetic profile from those diagnosed later, [finds an international study based on genetic data from more than 45,000 autistic people in Europe and the U.S]. So, there's more than one condition out there that's being diagnosed as "autism." This, of course, messes with the debate about causes; one version of autism may be caused by something for which the evidence is very weak overall. "The term 'autism' likely describes multiple conditions," said Dr Varun Warrier, from Cambridge's department of psychiatry, senior author of the research. "For the first time, we have found that earlier and later diagnosed autism have different underlying biological and developmental profiles."

"It is a gradient," added Warrier. "There are also many other factors that contribute to age of diagnosis, so the moment you go from averages to anything that is applicable to an individual, it's false equivalency."

The analysis has been published in the journal Nature.

Cancer rates among people aged 15 to 49 have increased 10% since 2000 even as rates have fallen among older populations. Young women face an 83% higher cancer rate than men in the same age range. A 150,000-person study presented at the American Association for Cancer Research meeting found millennials appear to be aging biologically faster than previous generations based on blood biomarkers. That acceleration was associated with up to 42% increased risk for certain cancers including lung, gastrointestinal and uterine malignancies.

Researchers are examining the "exposome" -- the full range of environmental exposures across a person's life. Studies have linked early-onset cancers to medications taken during pregnancy, ultra-processed foods that now account for more than half of daily calorie intake in the United States, circadian rhythm disruption from artificial light and shift work, and chemical exposures. Gary Patti at Washington University is using zebrafish exposed to known and suspected carcinogens to track tumor development. His lab has developed systems to scan blood samples for tens of thousands of chemicals simultaneously to identify signatures appearing more frequently in early-onset cancer patients.