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Now, one team of chemists has hit upon a curiously effective and consistent trick to prod the organisms to start synthesizing novel molecules: Cheerios inside bags. Scientists grew a soil fungus for four weeks in a bag full of Cheerios and discovered a new compound that can block biofilm formation by an infectious yeast. The chemists claim that Cheerios are by far the best in the cereal aisle at growing chemically productive fungi.
The first person to bring Ebola to Nigeria was Patrick Sawyer, who left a hospital in Liberia against the wishes of the medical staff and flew to Nigeria. Once Sawyer arrived, it became obvious that he was ill when he passed out in the Lagos airport, and he was taken to a hospital in the densely packed city of 20 million. Once the country's first Ebola case was confirmed, Port Health Services in Nigeria started a process called contact tracing to limit the spread of the disease and created an emergency operations center to coordinate and oversee the national response. Health officials used a variety of resources, including phone records and flight manifests, to track down nearly 900 people who might have been exposed to the virus via Sawyer or the people he infected. As soon as people developed symptoms suggestive of Ebola, they were isolated in Ebola treatment facilities. Without waiting to see whether a "suspected" case tested positive, Nigeria's contact tracing team tracked down everyone who had had contact with that patient since the onset of symptoms making a staggering 18,500 face-to-face visits.
The US has many of these same procedures in place for containing Ebola, making the risk of an outbreak here very low. Contact tracing is exactly what is happening in Dallas right now; if any one of Thomas Eric Duncan's contacts shows symptoms, that person will be immediately isolated and tested. "That experience shows us that even in the case in Nigeria, when we found out later in the timeline that this patient had Ebola, that Nigeria was able to identify contacts, institute strict infection control procedures and basically bring their outbreak to a close," says Dr. Tom Inglesby. "They did a good job in and of themselves. They worked closely with the U.S. CDC. If we can succeed in Nigeria I do believe we will stop it here."
University of Washington research on children who began life in these institutions shows that early childhood neglect is associated with changes in brain structure. A paper published this month in Biological Psychiatry shows that children who spent their early years in these institutions have thinner brain tissue in cortical areas that correspond to impulse control and attention. "These differences suggest a way that the early care environment has dramatic and lasting effects for children's functioning," said lead author Katie McLaughlin, a UW assistant professor of psychology.
Since 2000, the Bucharest Early Intervention Project has worked to document and treat the children's health. McLaughlin joined the team about six years ago to focus on brain development. This study is among the first in any setting to document how social deprivation in early life affects the thickness of the cortex, the thin folded layer of gray matter that forms the outer layer of the brain. The study provides "very strong support" for a link between the early environment and ADHD, McLaughlin said.
The second effect of World War One took place in the US. Starting in 1917 when the US entered the war, there was a wave of anti-German hysteria that swept the country. In Ohio, Wisconsin and Minnesota there were many, many German speakers. World War One changed all that. "German is criminalized in 23 states. You're not allowed to speak it in public, you're not allowed to use it in the radio, you're not allowed to teach it to a child under the age of 10," says Gordin. The Supreme Court overturned those anti-German laws in 1923, but for years they were the law of the land. What that effectively did, according to Gordin, was decimate foreign language learning in the US resulting in a generation of future scientists who came of age with limited exposure to foreign languages. That was also the moment, according to Gordin, when the American scientific establishment started to take over dominance in the world. "The story of the 20th Century is not so much the rise of English as the serial collapse of German as the up-and-coming language of scientific communication," concludes Gordin.
"The leading alternative is a design known as step-wedge, which essentially uses time to create a control group. In this design, researchers take advantage of the inescapable reality that large-scale trials can't give everyone the vaccine on the exact same date; they compare the rates of infection in people already vaccinated with those who have yet to receive the shots. Barney Graham, a virologist ... says "people are more comfortable" with the step-wedge design, because everyone in such a study would get the Ebola vaccine. But statistically speaking, this design makes it more difficult to determine the vaccine's worth, and it takes longer." NY Mag has a related story summarizing the treatments currently being used to fight Ebola.